ORGANISATION/COMPANYUniversity of Bergen
RESEARCH FIELDMedical sciences › Medicine
RESEARCHER PROFILEEstablished Researcher (R3)Recognised Researcher (R2)
APPLICATION DEADLINE20/05/2018 12:00 - Europe/Brussels
LOCATIONNorway › Bergen
TYPE OF CONTRACTOther
HOURS PER WEEK40
The Lorens Lab at the University of Bergen Centre for Cancer Biomarkers (CCBIO), Centre of Excellence and Department of Biomedicine is seeking postdoctoral researchers interested in high-dimensional mass cytometry analysis of tumor-immune interactions in clinical samples. The goal of our research is to understand the role of the AXL receptor tyrosine kinase in acquired resistance to anti-cancer therapy. AXL signaling regulates both tumor intrinsic and innate immune mechanisms in the tumor microenvironment that engender epithelial plasticity and subvert anti-tumor immunity. The primary objective of this project is to determine how AXL regulates tumor-immune crosstalk in the context of targeted and immunotherapy, using unique patient tumor biopsy samples from an ongoing AXL inhibitor (BGB324) phase II clinical trial (NCT02872259) and advanced experimental murine tumor models.
The candidate will be the main driver of this project and will focus on generating and analyzing high-dimensional mass cytometry datasets to measure AXL-mediated tumor-immune interactions in clinical samples at the single-cell level. This will entail application of various data-analysis methods and visualization approaches.
For further information please contact Prof. James Lorens, e-mail: firstname.lastname@example.org
A recent mass cytometry article from the group can be found here: http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30490-X
Qualifications and qualities
- The candidate must hold a Ph.D. degree (or submitted their doctoral dissertation for evaluation within the closing date of the application) in immunology, cancer research or computational biology. It is a condition for the appointment that the dissertation is approved.
- The candidate must have extensive experience in computational biology/bioinformatics methodologies. Familiarity with mass cytometry and/or high dimensional analysis of single cell level data sets is particularly favorable.
- A background in immunology is desirable.
- The candidate should be fluent in spoken and written English.
- Personal skills will be emphasized. The candidate should be able to work independently and interactively in a team setting, be motivated and responsible, and also have enthusiasm for research.
We can offer
- An enriching work environment
- Salary level 57 (code 1352/pay framework 24.1) currently NOK 490 900 gross p.a., with a degree in Medicine or Dentistry level 59 (code 1352/pay framework 24.3) currently NOK 508 800 gross p.a., with a medical specialization level 61 (code 1352/pay framework 24.5) currently NOK 527 500 gross p.a. on the government salary scale. Further promotion will be after service seniority in the position. A pension contribute of 2 % will be deducted and deposited to the state pension scheme.
- A good pension scheme in the Norwegian Public Service Pension Fund
- Inclusive workplace
- Good welfare benefits
For more information and access to the application portal see: https://www.jobbnorge.no/en/available-jobs/job/151486/postdoctoral-fello...
Application deadline: May 20, 2018
EURAXESS offer ID: 301053